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TECHMart

MASTIC provides a platform for technology transfer to enhance the application of local technology towards the development of the country's S&T capabilities. This database contained information on local products or technologies with potential for commercialisation resulting from R&D activities. This showed a selected products or technologies in TECHMart database.

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ID : tm3148212453


Toothbrush with Bristles in an Isosceles Configuration (Pro-dental Revolution)

The unique feature/inventive step of the revolution toothbrush is the 45 degree angled bristle comprising of three different heights but with equal length forming two brushing surfaces for better cleaning. Bristles of soft, medium and hard texture are incorporated for triple actions brushing comfort. Bristles head can be made as disposable upon consent of manufacturer.

Kepala Batas Pulau Pinang

ID : tm3148312454


Meliodot TM Enzyme Immunoassay kit: A New Diagnostic Test kit for the Diagnosis Melioidosis

Melioidosis is a mysterious fatal infectious disease of man and animals with many unpredictable clinical outcomes that mimics many other infectious diseases. It is caused by urkholderia pseudomallei, a Gram negative environmental bacterium. Anyone in the society and especially members of the military is at risk of getting the infection though direct contact with soil and water. Increased susceptibility to infection with fatal complication is particularly noted in immunocompromised individual.

Kepala Batas Pulau Pinang

ID : tm3148412455


Medi Bike Exerciser : Penambahbaikan Teknik Terapi Senaman Untuk Pesakit Yang Mengalami Masalah Menggerakkan Anggota Atas Dan Bawah.

Ramai pesakit yang mengalami masalah kelemahan otot (paresis), kelumpuhan (stroke), ketidakseimbangan dan masalah koordinasi pergerakan anggota badan atas (atas pinggang) dan bawah (bawah pinggang) yang perlu melakukan aktiviti senaman anggota badan atas dan bawah yang lama dan memenatkan. Kini, bilangan pesakit menjalani rawatan rehabilitasi semakin meningkat dan tempoh pemulihan yang panjang. Punca utama masalah ini adalah kerana senamansecara berasingan dan tiada peralatan yang sesuai. Selain itu, masalah masa, perawat dan peralatan terhad selain rawatan yang tidak efektif serta kos pembelian alatan/mesin rawatan yang tinggi. Punca utama masalah ini adalahkerana senaman secara berasingan dan tiada peralatan yang sesuai. Selain itu, masalah masa, perawat dan peralatan terhad selain rawatan yang tidak efektif serta kos pembelian alatan/mesin rawatan yang tinggi. Oleh itu, kami telah mencipta alat senaman gabungan untuk anggota atas dan anggota bawah badan manusia supaya aktiviti senaman boleh dijalankan serentak menggunakan Medi-bike Exercise. Struktur Medi-Bike Exerciser yang ringkas serta boleh dilaras mengikut kedudukan dan ketinggian pesakit bukan sahaj dapat memberikan keselesaan kepada pesakit, tetapi juga dapat mengekalkan postur tubuh badan yang ergonomik.

Kepala Batas Pulau Pinang

ID : tm3148512456


A Novel Drug-Drug and Drug-Herb Interactions Prediction Platform

Adverse drug reactions (ADR) as a result of drug-drug, drug-herb and drug-food interactions are a growing concern in the health care setting. The cytochrome P450enzymes play a key role in the metabolism of a wide variety of compounds. Inhibition of cytochrome P450 enzymatic activities due to the presence of an inhibitor or an induction of the cytochrome by an inducer are the most common mechanisms underlying drug interactions. Predicting the ability of a drug or herbal medicine to modulate CYP expression at an early stage of drug discovery will reduce the risk of failure in the market and to ensure product safety. A drug-drug and drug-herb interaction platform service to assess the safety of drugs and standardized herbal preparations was developed. It is a triple service platform consisting of a novel multiplex qRT-PCR assay to detect the mRNA expression of CYP1A2, CYP2D6, CYP3A4, a novel in vitro CYP3A4 protein expression assay utilizing a recombinant HepG2 cell line expressing GFP protein regulated by the CYP3A4 promoter, an optimized in silico screening protocol and CYP3A4 substrate-specific inhibition assays, to assess the inhibition activities of chemical entities or standardized herbal products on the CYP3A4 enzymatic activity. Utilizing these strategies, the effects of a compound/herbal extract on the cytochrome mRNA, protein expression and enzymatic activities on liver cells can be carried out in a time saving, cost effective and high throughput manner. The safety assessments and subsequent in vitro prediction of possible risks of interactions between drugs and herbal compounds can be objectively determined.

Kepala Batas Pulau Pinang

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