Bio-enhancers synergize the activity of drugs by various mechanism and help in curing diseases,shortening the duration of treatment and improving patient quality of life.Despite many developments, TB is still more fatal among infectious diseases and a combination of drugs is recommended for a period of 3-9 months. With this in view, a natural bio-enhancer of isoniazid has been formulated and investigated for pre-clinical studies.STANEXTIB has shown the ability to enhance the activity of isoniazid to a level of 75%.The combination containing STANEXTIB and isoniazid (75% less) has shown activity equivalent to MIC of isoniazid 0.4??g/ml. Therefore,the concomitant use of STANEXTIB with isoniazid may improve drug compliance and reduce drug related side effects especially in long terms use of antibiotics.STANEXTIB has been prepared from a refined standarized extract of Piper sarmentosum. STANEXTIB has been evaluated for safety using animal models. STANEXTIB has been investigated using pharmacokinetic parameters involving absorption,distribution and excretion.The product has been evaluated for accelerated stability studied for the shelf life data. STANEXTIB is evidence based bio-enhancer of isoniazid ,an anti TB drug with complete pre clinical data for efficiancy, safety, bioavailability and stability and can be formulated in various dosage forms.