Typhoid fever remains as a public health problem in many developing countries. There is a need for an alternative test for typhoid that is rapid, sensitive, specific and cost-effective. A novel approach to outer membrane studies by Prof Asma Ismail and her research team has paved the way for the discovery of 50kDa, a specific outer membrane protein for S. typhi. The specific protein was used to developed a rapid dot EIA test for typhoid called TYPHIDOTTM that detects for the presence of specific IgM and IgG to the 50 kD antigen. The test became a breakthrough in typhoid diagnosis since 1896 and could produce results within an hour compared to 2-5 days via the conventional culture method and 2 weeks via the serologiccal Widal test.