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Evaluation On The Safety Profile Of Herbal Product On Male Reproductive System: Laboratory Evaluation In Male RATS
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Evaluation On The Safety Profile Of Herbal Product On Male Reproductive System: Laboratory Evaluation In Male RATS
Studies to evaluate the possible toxic effect of two different extracts from similar plant species on the male reproductive system of rats have been carried out. Male rats were treated with the herbal extract by gavaging for four-week duration. Mating were allowed in all animals (1 male: 3 females) daily for three hours in a dark quiet room for a maximum period of 3 weeks. At the end of the study, blood was collected for hormonal assays and all male rats were sacrificed. Examinations of the sperms and testis were carried out. Result showed that both extracts increased the reproductive performance (Libido Index) and sexual hormones concentrations in rats. Examinations of the sperms and histology of the testis however showed that the extracts cause severe damage to the spermatogenesis and severe interstitial edema of the testis. There were alteration in reproductive organs weight, significantly low sperm count, spermatic count, daily sperm production and high number of abnormal sperms. The No Observable Adverse Effect Level (NOAEL) of the extracts was found to be 1.0 mg/kg/day. These findings suggest that evaluations on the toxic potential of all herbal products on reproductive systems are important to prevent major harmful effect to the consumers. Our research team will be offering this service to local and international parties at reasonable cost.

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Herbal Medicine Research Team, Dept of Pharmacology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia
16150 Kubang Kerian
Kelantan
Malaysia

Full Name [1]
Assoc. Prof. Dr. Siti Amrah Sulaiman
Email [1]
sbsamrah@kb.usm.my