Liver diseases are considered as one of the most serious health problems given that liver is a major and important organ which is responsible for detoxification and deposition of endogenous and exogenous substances. Steroids, vaccines and antiviral drugs, which have been employed as a therapy for liver diseases, have potential adverse effects especially when administered for long terms. Therefore, it is essential to search novel agents that are efficient and have minimum side effects. Hence, hepatoprotective drugs from plant sources seem to be attractive alternatives. Herbal plants, such as Momordica charantia, Parkia speciosa; Homalanthus species, Andrographis paniculata, Cymbopogon citrates, Orthosiphon stamineus, Strobilanthes crispus, Merremia bornensis, Lonicera Japonica, Centella asiatica, Hoya coranaria and Eleusine indica, which are used as medicinal plants by local ethnic communities in Sabah, were selected for an evaluation of their antioxidant and hepatoprotectibe properties as well as their possible mechanism (s) of action.