Cancer is the third major cause of mortality, accounting for more than seven million deaths per year worldwide. In Malaysia, approximately two million people, representing 7% of the total population, suffer from different types of cancerous diseases, and the figure is estimated to double by 2035. While cancer is an incurable disease, prevention is considered as an important treatment in cancer control. Most drugs currently available in the markets for the treatment of incurable diseases have limited potential because they are very toxic or expensive, and thus beyond the reach of the majority of the people. Hence, treatments without these disadvantages are needed. Diet can play a vital role in the prevention of various incurable diseases such as cancer and diabetics. Medicinal plants, fruits as well as vegetables with diversified pharmacological properties have been shown to be rich sources of ingredients with potential to prevent the incurable diseases. There is now an urgent need to search for novel and effective ingredients that may prevent the various incurable diseases. Convolvulaceae is a large and economically important family of flowering plants, and it is commonly known as the legume family or pulse family. About 900-1000 species of tropical climbing plants in this family are native to southern Asia. The Borneo Island is considered to have the highest species diversity in the world. Some species are found on the Borneo Island. Most of the species are being used by the Sabah ethnic communities as herbal medicine. They are also using the Merremia borneensis for the treatment of cancer, breast cancer, and fever. The literature search has revealed that still no works have been done on this plant by past researchers. For this reason, the aim of this work was to investigate the total phenolics, flavonoids, and antioxidant activities as well as phytochemical profiling of different organic extracts of this species which is native to Borneo.